What is Ipamorelin?

Ipamorelin is one of several synthetic met-enkephalin analogs that include unnatural D-amino acids. They were developed for their growth hormone (GH) releasing activity, then called GH secretatogues. They lack opioid activity but are potent stimulators of GH release. These secretatogues are distinct from the growth hormone releasing hormone (GHRH or GHRF) in that they share no sequence relation and derive their function through action at a completely different receptor, the ghrelin receptor.
Ipamorelin mainly functions in both the brain and liver, which makes it unique in the world of age prevention and youth recovery. In the brain, studies in animal subjects demonstrated that it stimulates the pituitary gland, which is a pea-shaped gland located at the bottom of the hypothalamus in the base of the brain.
The primary function of the pituitary gland is to secrete specific hormones to regulate multiple endocrine system-related processes, including:
• Growth and metabolism
• Pain relief
• Temperature regulation
In the liver, a related study using the same test subjects determined that ipamorelin induces a significant increase in the hepatic production of IGF-1 levels.
As discussed in detail above, hGH therapy involves the direct injection of synthetic HGH, which stimulates igf-1 supplements production in the liver. In contrast, sermorelin is a GH secretagogue that stimulates the secretion of endogenous GH and the resulting normal downstream processes including IGF-1 production.
Like sermorelin, ipamorelin functions as a GH secretagogue. What makes ipamorelin unique is that it also stimulates the production of IGF-1 in the liver independent of GH. This means that ipamorelin has the ability to more potently stimulate systems related to growth and repair throughout the body. This means that it may be one of the best hGH therapeutic options available.
An important consideration for patients participating in a GH secretagogue-based therapy is whether it promotes an increase in the production of the enzyme ghrelin, which is undesirable for most patients. Keep in mind that ghrelin secretion stimulates hunger. However, ipamorelin does not increase ghrelin levels.
Another important difference is that ipamorelin does not significantly boost cortisol levels. Patients on different GH secretagogue-based therapies have reported side effects such as jitters, cold sweats, or nervousness, which could be due to the effects of their therapy on cortisol levels. Because ipamorelin does not have these effects, patients can benefit from just the positive aspects of GH therapy, while keeping unwanted side effects at bay.
Benefits
Several studies have shown that the ability of ipamorelin to stimulate the pituitary gland and liver might elicit a number of physiological effects, including:
• Strengthening the joints and connective tissue
• Increasing the bone mass density and strength
• Improving skin tone
• Rejuvenating joints
• Increased adipose tissue (body fat) breakdown
Together, these characteristics suggest that ipamorelin could play a crucial role in slowing down the aging process.
Side effects of Ipamorelin
Like most drugs on the market, there are always side effects, but thankfully, with iPamorelin, the effects are very limited.
In terms of estrogenic side effects, one does not have to worry about gynecomastia or anything similar. It has no effects on those parts of the body. There can be some minor water retention and swelling of the ankles and feet, but that is typically only in the beginning dosages of this compound.
There are no androgenic effects of this drug, so it is safe for use by women and men don’t have to expect any changes to their emotions as most androgens tend to do.
There are no cardiovascular side effects, and in fact, some users might actually report improved cardiovascular markers after using this compound.
There is also no reason to worry about hepatoxicity because it is not toxic to the liver.
Most minor side effects of this compound occur in the very early stages and can include possible light headaches, sore injection sites, and elevated levels of prolactin. However, the elevated prolactin can be dealt with thanks to Cabergoline. In the presence of testosterone based anabolic steroids which aromatase, gynecomastia may be seen indirectly.


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